Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency
نویسندگان
چکیده
منابع مشابه
Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is abundantly expressed in latently infected sensory neurons. In small animal models of infection, expression of the first 1.5 kb of LAT coding sequences is necessary and sufficient for wild-type reactivation from latency. The ability of LAT to inhibit apoptosis is important for reactivation from latency. Within the fir...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2009
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.013318-0